Acta Biologica

Wcześniej: Zeszyty Naukowe Uniwersytetu Szczecińskiego. Acta Biologica

ISSN: 2450-8330     DOI: 10.18276/ab.2017.24-05
CC BY-SA   Open Access 

Lista wydań / No. 24
QS – systems communication of Gram-negative bacterial cells
(Systemy komunikacji QS w komórkach bakterii Gram-ujemnych)

Rok wydania:2017
Liczba stron:11 (39-49)
Słowa kluczowe: komunikacja międzygatunkowa historia quorum sensing quorum sensing u Vibrio i Pseudomonas aeruginosa synteza autoinduktora AI-2
Autorzy: Alicja Ziemichód
University of Szczecin, Department of Genetics, Faculty of Biology

Bogumiła Skotarczak
University of Szczecin, Department of Genetics, Faculty of Biology

Abstrakt

Quorum sensing (QS) jest mechanizmem komunikacji używanym przez bakterie do rozpoznawania zmian w zagęszczeniu populacji i kontroli ekspresji genów, który jest ważny zarówno w komunikacji wewnątrz jak i pomiędzy gatunkowej oraz kontroluje interakcje bakteria- -gospodarz. QS jest procesem, w którym komórki bakteryjne wykrywają progową koncentrację cząsteczek sygnałowych w środowisku zewnętrznym, a następnie, po przekroczeniu tego progu, odpowiadają swoiście i modyfikują swoje zachowanie przez zmiany w ekspresji genów. Regulacja ekspresji genów w odpowiedzi na gęstość komórek bakteryjnych w populacji jest kluczowym fenomenem w mechanizmie QS i jest stosowana zarówno przez bakterie Gramujemne, jak i Gram-dodatnie. U bakterii Gram-ujemnych białko LuxR odgrywa kluczową rolę w systemie QS jako rodzaj regulatora transkrypcji oraz wspólnie z białkiem LuxI i cząsteczkami sygnałowymi uczestniczy w różnych procesach biologicznych takich jak kodowanie czynników wirulencji i biosyntezie antybiotyków, w transferze plazmidów, bioluminescencji i formowaniu biofilmu. W pracy zaprezentowano nowe badania, które przybliżają te niezwykłe cząsteczki sygnałowe, nowe komponenty regulatorowe i heterogenność QS-systemu u bakterii Gram-ujemnych.
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