Acta Biologica

Wcześniej: Zeszyty Naukowe Uniwersytetu Szczecińskiego. Acta Biologica

ISSN: 2450-8330     eISSN: 2353-3013    OAI    DOI: 10.18276/ab.2020.27-08
CC BY-SA   Open Access   DOAJ

Lista wydań / No. 27
Changes in innate and adaptive immune response to Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus -RHDV) infection
(Zmiany we wrodzona i nabytej odpowiedź immunologicznej po zakażeniu Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus – RHDV))

Autorzy: Beata Hukowska-Szematowicz ORCID
Institute of Biology, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland Molecular Biology and Biotechnology Center, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland
Słowa kluczowe: neutrofil limfocyty infekcja wirusowa królik wirus krwotocznej choroby królików
Data publikacji całości:2020
Liczba stron:15 (77-91)
Cited-by (Crossref) ?:

Abstrakt

Lagovirus europaeus GI.1 (Rabbit Haemorrhagic Disease Virus – RHDV) infekuje króliki do- mowe i dzikie na całym świecie, wywołując u nich krwotoczną chorobę królików (RHD-rabbit haemorrhagic disese). Z uwagi na fakt, że wpływ RHDV na organizm żywiciela, a dokładniej jego wpływ na układ odpornościowy, ma kluczowe znaczenie dla rozprzestrzeniania się tej infekcji u królików, bardzo ważne jest poznanie roli elementów układu odpornościowego w przebiegu zakażenia tym wirusem. Dlatego też celem badań było przedstawienie zmian we wrodzonej i nabytej odpowiedzi immunologicznej po zakażeniu trzema szczepami (V411, 1092V, Wika) Lagovirus europaeus GI.1 (RHDV), zidentyfikowanymi w różnym czasie. W za-kresie wrodzonej odpowiedzi immunologicznej zbadano dwanaście wskaźników, a w nabytej dziewięć. Uzyskane rezultaty wskazują na udział komórek PMN (polimorfonuklearnych, neu-trofilii) jako ważnych elementów w odpowiedzi na to zakażenie oraz rzucają nowe spojrzenie na udział limfocytów CD4+ Th i CD8+ Tc. Najbardziej immunogenny okazał się szczepem Wika z 1996 r.
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