Acta Biologica

Previously: Zeszyty Naukowe Uniwersytetu Szczecińskiego. Acta Biologica


ISSN: 2450-8330     eISSN: 2353-3013    OAI    DOI: 10.18276/ab.2020.27-09
CC BY-SA   Open Access   DOAJ

Issue archive / No. 27
MicroRNAs as new immunity regulators in viral and bacterial infections

Authors: Martyna Szumna
Institute of Biology, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland Molecular Biology and Biotechnology Center, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland

Beata Hukowska-Szematowicz ORCID
Institute of Biology, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland Molecular Biology and Biotechnology Center, University of Szczecin, Wąska 13, 71-412 Szczecin, Poland
Keywords: microRNA immunity viruses bacteria
Data publikacji całości:2020
Page range:16 (93-108)
Cited-by (Crossref) ?:

Abstract

MicroRNAs (miRNAs) – small, conserved RNA molecules, containing 22 to 25 nucleotides and occurring in the cells of living organisms. As regulatory molecules, they have enormous biological potential and can influence a number of cellular processes. In the context of immu-nology, the role of miRNAs as novel immunity regulators is invaluable. The miRNAs regulate immune phenomena at many levels - starting from the impact on the processes of maturation, proliferation and differentiation of the immune system cells, through the regulation of the secretion of their products, to the regulation of intracellular signalling pathways. In all these areas, the miRNAs can play the role of both an inducer and an inhibitor by appropriately increasing the intensity of or suppressing the immune processes they regulate. In the future, it will be possible to regulate the host’s immune response to the pathogen thanks to the properly controlled expression of miRNAs in the immune system cells.
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